Voiceover on iPad

Hello all,
I find myself struggling with Voiceover on my new iPad. I am quite comfortable with VO on my iPhone but with the increased form factor on the iPad and its different layout with multiple panes etc. I find it difficult to navigate some of my favorite apps like News, Podcast, Downcast etc. Are there some basic stuff I need to understand for navigating comfortably on the iPad? Any settings that will make my life easier? Any help will be welcome.
Thanks/